IV Edizione della Scuola delle Sostanze Naturali e di Chimica Biorganica

Domenica, 5 giugno

16:00 – 18:00 Registrazioni

17:00 Cerimonia di Apertura

17:30 PL1: D. Newman – The State of the Art in Developing Drug Candidates from Marine Organism
18:15 PL2: R. Andersen – The Discovery and Preclinical Evaluation/Development of Marine Natural Product Drug Leads

Welcome Reception at Hotel Royal Continental

Lunedì, 6 Giugno

Morning Session: T1 Bioactive marine natural products
Introduction

09:00 PL3: T. Molinski - Synthesis, Stereochemistry of Marine Natural Products: Structural Knowledge and Pathways to Translational Medicine
09:45 Nea1: Taglialatela
10:00 Nea2: Rondinelli
10:15 Nea3: Lombardo
10:30 Nea4: Hochmuth
10:45 - 11:10 Coffee break
11:10 PL4: M. Bourguet-Kondracki - "Exploring the Origin of Secondary Metabolites Using the Mediterranean Sponge Clathrina clathrus and its Associated Bacteria as Biological Model"
11:55 Nea5: Menna
12:15 Nea6: Teta
12:35 O1: Guo

12:55 – 14:00 Lunch

Afternoon Session : T2 Molecular Biology
Introduction

14:00 PL5 : W. Gerwick – Integrating Genomics, Biosynthesis and Analytical Chemistry to Discover New Classes of Bioactive Secondary Metabolites from Marine Cyanobacteria.
14:45 O2: Goss
15:05 O3: Schöder
15:25 PL6 : J. Piel – Mining Polyketide Pathways for Natural Product Discovery and Production
16:10 - 16:40 Coffee break
16:40 PL7 : Moore – Genomics-Inspired Discovery and Bioengineering of Marine Microbial Natural Product Drug Leads
17:25 O4: Fullone
17:45 O5 Schäberle
18:05 O6: Panno

20:00 Social Dinner

Martedì, 7 Giugno

Morning Session: T3 From Mechanism of Action to Drug Design
Introduction

09:00 PL8: T. Carlomagno – Functional Mechanisms of Drugs Studied by NMR: Methodology and Applications
09:45 PL9 C. Ferlini - The Cytoskeletal Gateway of Survival as a Novel Target for Antitumor Agents
10:30 - 10:50 Coffee break
10:50 PL10 : G. Cruciani - The State of Art in Structure Metabolism Relationships
11:35 OL7 Rossini
11:55 OL8 Peigneur
12:15 OL9 Stevens
12:35 OL12 Manzo

12:55 – 16:00 Lunch and Poster Session

Mercoledì, 8 Giugno

Morning Session: T4 Druggable Compounds
Introduction

09:00 PL11: C. Cuevas – Development of Yondelis® as an Anticancer Drug
09:45 PL 12: G. Carter – Strategies for Natural Products Drug Discovery
10:30 O10: Deslandes
10:50-11:15 Coffee break
11:15 PL13: L. Meijer – Protein Kinases Relevant to Human Diseases: Pharmacological Inhibitors Derived from Marine Organisms, a Selection of Examples
12:00 PL14: W. Cabri – Natural Products Architectures in Drug Discovery & Development
12:45 O11 Rodriguez Martins

13:05 Closing Remarks

13:15 Opening Scuola Minale

13:15 – 15:00 Lunch

15:00 ML1: M.V. D’Auria – Alkene metathesis: a “magic” tool in the synthesis of natural products
16:00 ML2: A. Fontana - Biosynthesis of marine functional metabolites
17:00 – 17:15 Break
17:15 ML3 S.Abbate – Vibrational Circular Dichroism (VCD) for the assignment of the absolute configuration of natural products: use and limitations
18:15 ML4 G. Bifulco - Quantum chemical calculation of NMR parameters in the stereochemical determination of organic compounds

Giovedì, 9 giugno

Morning Session

09:00 ML5: A. Bassoli – Taste Chemistry Makes Sense: from Food Plants New Bioactive Compounds for Agrifood and Pharmaceutical Industry
10:00 ML6: P.Ciminiello – Marine Biotoxins and Their Noxious Impact on Public Health
11:00-11:30 Break
11:30 ML7: A. Molinaro – Microbial Glyco-Conjugates and Eukaryotic Innate Immunity
12:30 ML8: G. Guella – Adventures into Lipidomics World of a Natural Products Chemists

13:30 – 15:30 Lunch

Pratical Session - Mangoni and Casapullo

15:30 Working on 700 MHz: from Theory to Practice

17:30 Closing Remarks

Programma

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